High Blood Pressure Pill Cuts Risk Of Parkinson's Disease

Daily Science Journal (Feb. 10, 2008) — People taking a widely used group of drugs known as calcium channel blockers to treat high blood pressure also appear to be cutting their risk of Parkinson's disease, according to a new study.

The study involved 7,374 men and women over age 40. Half of the group had Parkinson's disease; the other half did not have Parkinson's disease. Among both groups, nearly half used high blood pressure medications, such as calcium channel blockers, ACE inhibitors, AT II antagonists and beta blockers.

The study found people who were currently long-term users of calcium channel blockers to treat high blood pressure lowered their risk of Parkinson's disease by 23 percent compared to people who didn't take the drugs. There was no such effect among people taking ACE inhibitors, AT II antagonists and beta blockers.

"Long-term use of calcium channel blockers was associated with a reduced risk of developing Parkinson's disease while no such association was seen for other high blood pressure medicines," said study author Christoph R. Meier, PhD, MSc, with University Hospital Basel in Switzerland.

Meier says more research is needed to determine why calcium channel blockers appear to protect against Parkinson's disease, whether this is indeed a causal association, and why the other high blood pressure medications do not offer a reduced risk.

This research was published in the February 6, 2008, online issue of Neurology®, the medical journal of the American Academy of Neurology.

Adapted from materials provided by American Academy of Neurology.

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Chronic Pain Harms The Brain

Daily Science Journal (Feb. 7, 2008) — People with unrelenting pain don't only suffer from the non-stop sensation of throbbing pain. They also have trouble sleeping, are often depressed, anxious and even have difficulty making simple decisions.

Comparison of brains. These images show the brain from the left side, demonstrating striking differences between chronic pain patients and healthy subjects. They illustrate with colors how much activation (red-yellow) or deactivation (dark/light blue) was found at each location. (Credit: Image courtesy of Northwestern University)

In a new study, investigators at Northwestern University's Feinberg School of Medicine have identified a clue that may explain how suffering long-term pain could trigger these other pain-related symptoms.

Researchers found that in a healthy brain all the regions exist in a state of equilibrium. When one region is active, the others quiet down. But in people with chronic pain, a front region of the cortex mostly associated with emotion "never shuts up," said Dante Chialvo, lead author and associate research professor of physiology at the Feinberg School. "The areas that are affected fail to deactivate when they should."

They are stuck on full throttle, wearing out neurons and altering their connections to each other.

This is the first demonstration of brain disturbances in chronic pain patients not directly related to the sensation of pain.

Chialvo and colleagues used functional magnetic resonance imaging (fMRI) to scan the brains of people with chronic low back pain and a group of pain-free volunteers while both groups were tracking a moving bar on a computer screen. The study showed the pain sufferers performed the task well but "at the expense of using their brain differently than the pain-free group," Chialvo said.

When certain parts of the cortex were activated in the pain-free group, some others were deactivated, maintaining a cooperative equilibrium between the regions. This equilibrium also is known as the resting state network of the brain. In the chronic pain group, however, one of the nodes of this network did not quiet down as it did in the pain-free subjects.

This constant firing of neurons in these regions of the brain could cause permanent damage, Chialvo said. "We know when neurons fire too much they may change their connections with other neurons and or even die because they can't sustain high activity for so long," he explained.

'If you are a chronic pain patient, you have pain 24 hours a day, seven days a week, every minute of your life," Chialvo said. "That permanent perception of pain in your brain makes these areas in your brain continuously active. This continuous dysfunction in the equilibrium of the brain can change the wiring forever and could hurt the brain."

Chialvo hypothesized the subsequent changes in wiring "may make it harder for you to make a decision or be in a good mood to get up in the morning. It could be that pain produces depression and the other reported abnormalities because it disturbs the balance of the brain as a whole."

He said his findings show it is essential to study new approaches to treat patients not just to control their pain but also to evaluate and prevent the dysfunction that may be generated in the brain by the chronic pain.

The study will be published Feb. 6 in The Journal of Neuroscience. Chialvo's collaborators in this project are Marwan Baliki, a graduate student; Paul Geha, a post-doctoral fellow, and Vania Apkarian, professor of physiology and of anesthesiology, all at the Feinberg School.

Adapted from materials provided by Northwestern University.

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Migraines: Options To Prevent And Treat The Pounding Pain

Daily Science Journal (Sep. 12, 2007) — Migraines are more than a bad headache. As nearly 30 million Americans can attest, the throbbing pain of a migraine can be debilitating, lasting from a few hours to several days. The condition can be aggravated by light, sounds, odors, exercise, even routine physical activities. Nausea, with or without vomiting, may occur.

Nearly 30 million Americans suffer from migraines. (Credit: iStockphoto/Guillermo Perales Gonzalez)

Fortunately, treatment helps most people who have migraines.

Doctors may recommend preventive medications for patients who have two or more debilitating episodes a month. Typically the medication is taken at regular intervals, often daily. Antidepressants, anti-seizure medications and cardiovascular drugs may help prevent migraines.

Infrequently, nonprescription nonsteroidal anti-inflammatory drugs (NSAIDs) such as ibuprofen (Advil, Motrin, others) or naproxen sodium (Aleve, others) may help. Injections of botulinum toxin type A (Botox) is an alternative for people who can’t take or don’t respond well to preventive medications. However, this use of Botox for migraine prevention is not approved by the Food and Drug Administration.

Pain relief drugs for migraines should be taken as soon as symptoms begin. Mild migraines may respond to NSAIDs or aspirin. A moderate migraine may respond to a nonprescription combination of a drug containing acetaminophen, aspirin and caffeine. Other drug categories used to treat pain include triptans, which mimic the action of the brain chemical serotonin; anti-nausea and related drugs; and ergots, which were used for decades before the more recent introduction of triptans.

Some patients find relief from alternative therapies. The National Institutes of Health has concluded that acupuncture may help control headaches. A study in the journal Headache showed that a combination of yoga, breathing exercises and relaxation techniques reduces migraine frequency and pain.

Some find benefit in herbal remedies, such as butterbur, which appears to be safe if taken for a short period to prevent migraines. In addition, the supplement coenzyme Q10 appears to reduce migraine frequency for some. Patients who consider alternative therapies should consult their physician about the pros and cons and to prevent any drug interactions.

The September issue of Mayo Clinic Health Letter provides more information on treatments to prevent migraines and stop the pain.

Adapted from materials provided by Mayo Clinic, via Newswise.

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