Fake Malaria Drugs Made In China: Tracking Down The Threat To Global Health

Daily Science Journal (Feb. 13, 2008) — A unique collaboration between scientists, public health workers and police has led to the arrest by the Chinese authorities of alleged traders of fake anti-malarial drugs in southern China and the seizure of a large quantity of drugs. The work, involving teams from across the globe, has highlighted both the growing threat posed by fake pharmaceuticals and the complexities of tracking down those responsible for the trade.

Counterfeit artesunate anti-malarial tablet with fake 'X-52' stamp as seen under UV light. (Credit: Newton PN, Fernandez FM, Plancon A, Mildenhall DC, Green MD,et al.)

Dubbed Operation Jupiter, the investigation was coordinated by the International Criminal Police Organisation (INTERPOL), the World Health Organization's Western Pacific Regional Office, and the Wellcome Trust-University of Oxford SE Asian Tropical Medicine Research Programme, in close cooperation with Chinese authorities. Scientists from 5 other laboratories analysed the composition of the fake drugs and their packaging.

Fake anti-malarial drugs are an increasingly serious problem, particularly in South-East Asia and Africa. In countries with a large burden of malaria, such as Myanmar (Burma), the Lao PDR, Cambodia and Viet Nam, as many as half of all artesunate tablets -- one of the most effective anti-malarial drugs -- is counterfeit.

Most of the fakes examined as part of Operation Jupiter contained no artesunate, and some contained a wide range of potentially toxic wrong active ingredients. Also of grave concern was the fact that counterfeiters sometimes included dangerously small amounts of artesunate in the tablets. This may be done to foil screening tests of drug quality, but these doses are too low to be efficacious, yet high enough to contribute to malaria parasites becoming resistant to this class of drugs.

"Artesunate, as part of artemisinin-based combination therapy, is vital for malaria treatment and is one of the most effective weapons we have against this terrible scourge," says Dr Paul Newton of the Wellcome Trust-University of Oxford SE Asian Tropical Medicine Research Programme. "Those who make fake anti-malarials have killed with impunity, directly through the criminal production of a medicine lacking active ingredients and by encouraging drug resistance to spread. If malaria becomes resistant to artesunate, the effect on public health in the tropics will be catastrophic."

In addition to analysing the chemistry of the samples, researchers used a technique known as forensic palynology to study pollen contamination within the fake tablets with the aim of tracking down the likely location of manufacture. The pollen evidence suggested that at least some of the counterfeit artesunate came from southern China, and this was supported by examination of the mineral calcite, found in some of the samples.

Armed with these findings by INTERPOL, Chinese authorities arrested a suspect in China's Yunnan Province in 2006. He is alleged to have traded 240,000 blisterpacks of counterfeit artesunate, enough to "treat" almost a quarter of a million adults with a medicine with no activity against a potentially fatal disease. Whilst the Chinese authorities were able to seize 24,000 of these packs, the remainder are alleged to have been sold at crossings on the border of Yunnan and Myanmar (Burma), accounting for almost a half of all blisterpacks of artesunate sold to the region.

The work of the Jupiter group highlights the need for more to be done internationally to support countries with a high prevalence of counterfeit anti-malarials in their attempts to combat this severe but under-recognised public health problem.

"Criminal investigations and legal action are important in disrupting and inhibiting the trade in fake medicines, but to be effective these will require financial support and resources," says Dr Newton. "Forensic tools may make it easier to identify the fake drugs and allow over-stretched police forces to focus on objective leads, greatly increasing the risks to counterfeiters of being caught. However, there are very few laboratories with the resources to perform detailed forensic chemistry or pollen analysis of fakes, particularly in the countries where they are most needed."

Journal citation: Newton PN, Fernandez FM, Plancon A, Mildenhall DC, Green MD,et al. (2008) A collaborative epidemiological investigation into the criminal fake artesunate trade in South East Asia. PLoS Med 5(2): e32.

Adapted from materials provided by Wellcome Trust.

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Biofuel Crops That Require Destroying Native Ecosystems Worsens Global Warming

Daily Science Journal (Feb. 12, 2008) — Turning native ecosystems into "farms" for biofuel crops causes major carbon emissions that worsen the global warming that biofuels are meant to mitigate, according to a new study by the University of Minnesota and the Nature Conservancy.

Aerial view of farmland in Indonesia. The conversion of peatlands for palm oil plantations in Indonesia ran up the greatest carbon debt, one that would require 423 years to pay off. (Credit: iStockphoto)

The carbon lost by converting rainforests, peatlands, savannas, or grasslands outweighs the carbon savings from biofuels. Such conversions for corn or sugarcane (ethanol), or palms or soybeans (biodiesel) release 17 to 420 times more carbon than the annual savings from replacing fossil fuels, the researchers said. The carbon, which is stored in the original plants and soil, is released as carbon dioxide, a process that may take decades. This "carbon debt" must be paid before the biofuels produced on the land can begin to lower greenhouse gas levels and ameliorate global warming.

The conversion of peatlands for palm oil plantations in Indonesia ran up the greatest carbon debt, one that would require 423 years to pay off. The next worst case was the production of soybeans in the Amazon, which would not "pay for itself" in renewable soy biodiesel for 319 years.

"We don't have proper incentives in place because landowners are rewarded for producing palm oil and other products but not rewarded for carbon management," said University of Minnesota Applied Economics professor Stephen Polasky, an author of the study. "This creates incentives for excessive land clearing and can result in large increases in carbon emissions.

"This research examines the conversion of land for biofuels and asks the question 'Is it worth it?'," said lead author Joe Fargione, a scientist for The Nature Conservancy. "And surprisingly, the answer is no."

Fargione began the work as a University of Minnesota postdoctoral researcher with Polasky, Regents Professor of Ecology David Tilman; he completed it after joining the Nature Conservancy. They, along with university researchers Jason Hill and Peter Hawthorne, also contributed to the work.

"If you're trying to mitigate global warming, it simply does not make sense to convert land for biofuels production," said Fargione. "All the biofuels we use now cause habitat destruction, either directly or indirectly. Global agriculture is already producing food for six billion people. Producing food-based biofuel, too, will require that still more land be converted to agriculture."

These findings coincide with observations that increased demand for ethanol corn crops in the United States is likely contributing to conversion of the Brazilian Amazon and Cerrado (tropical savanna). American farmers traditionally rotated corn crops with soybeans, but now they are planting corn every year to meet the ethanol demand and Brazilian farmers are planting more of the world's soybeans. And they're deforesting the Amazon to do it.

The researchers also found significant carbon debt in the conversion of grasslands in the United States and rainforests in Indonesia.

Researchers did note that some biofuels do not contribute to global warming because they do not require the conversion of native habitat. These include waste from agriculture and forest lands and native grasses and woody biomass grown on marginal lands unsuitable for crop production. The researchers urge that all fuels be fully evaluated for their impacts on global warming, including impacts on habitat conversion.

"Biofuels made on perennial crops grown on degraded land that is no longer useful for growing food crops may actually help us fight global warming," said Hill. "One example is ethanol made from diverse mixtures of native prairie plants. Minnesota is well poised in this respect."

"Creating some sort of incentive for carbon sequestration, or penalty for carbon emissions, from land use is vital if we are serious about addressing this problem," Polasky said.

"We will need to implement many approaches simultaneously to solve climate change. There is no silver bullet, but there are many silver BBs," said Fargione. "Some biofuels may be one silver BB, but only if produced without requiring additional land to be converted from native habitats to agriculture."

The work will be published in Science later this month and will be posted online Thursday, Feb. 7.

The work was supported by the University of Minesota's Initiative for Renewable Energy and the Environment and the National Science Foundation.

Adapted from materials provided by University of Minnesota.

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Finding New Oil In Long-exhausted Oil Wells

Daily Science Journal (Feb. 3, 2008) — Under contemporary conditions, it is more economically sound not to look for new oil fields but to overhaul old ones. Oil reappears from time to time in old deposits and long ago exhausted oil wells.

The earth's crust is similar to a sandwich cake, consisting of hard layers and fractured-porous layers saturated by various fluids, including oil. In some places, the crust is penetrated by an extremely dense network of fissures and ruptures. Ruptures form cavities located almost horizontally and united into a network. All this complicated system is in constant motion due to tectonic forces’ action. The layers are moving, fissures are widening and acting as a rubber bulb: liquid starts coming into formed interstice from surrounding porous layers. In case of significant tectonic tensions, liquid moves at large distances.

This phenomenon attracts attention of multiple researchers. Specialists of the Institute of Oil and Gas Problems under the guidance of Academician Dmitrievsky offer their explanation.

According to the researchers’ opinion, this mechanism of liquid movement in the crust is the most intense and universal among all possible ones. It acts both in ruptures and in thin fractured layers, which stretch at significant distances. Vibrations in the crust drive fluids along all possible directions, including horizontal and even downward directions. Migration occurs along lengthy cavities and fractures systems, located at the depth of 10 to 15 kilometers.

Liquid movement caused by widening of internal cavities is of vibrating character. Oil sometimes rushes in or sometimes floods back. The mode and period of vibration depend on the size of perturbed area. In large porous layers, the vibration period makes about 10 thousand years. In the ruptures, the period is shorter and it varies from a thousand to hundreds and even dozens of years, if rupture zones are located at small depths.

The researchers have investigated the carbohydrates migration process from the petroliferous stratum into the upper layers in several regions. An example can be the Romashinskoye oilfield in Tatarstan. The volume of produced oil there has significantly exceeded the previously asserted reserves. According to the TATANEFT Joint Stock Company’s data, more than 65% of oil in Tatarstan is produced in old oilfields exhausted by 80%. However, supplementary exploration of the known deposits allowed to increment reserves of oil by one and a half times within the last 25 years. In the Romashinskoye oilfield, the researchers also discovered old exhausted drillings with regenerated inflow of oil and oil with water.

The space of oil pools and their reserves increase with increasing rupture network density. It is interesting to note that the depth of sedimentary covering in the zone of the gigantic Romashinskoye oilfield does not exceed 2 kilometers on average, and this mantle does not possess significant oil potential. Most likely, oil cames to these locations from the direction of Pre-Ural downfold.

In the researchers’ opinion, to overhaul old oil deposits is currently much more profitable and efficient than expensive geological exploration works at new locations.

Adapted from materials provided by Informscience.

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Oil Exploration In Arctic Highly Risky: 'Response Gap' In Case Of Oil Spill, According To New Report

Daily Science Journal (Jan. 31, 2008) — Arctic marine conditions contribute to an oil spill “response gap” that effectively limits the ability to clean up after an oil spill.

A new report commissioned by WWF concludes that the only way to avoid the potentially devastating environmental risks is to ensure that no more of the Arctic is opened up to oil development until the response gap is closed.

“The ability to effectively clean up an arctic marine oil spill is a critical component of the risk equation,” said Dr Neil Hamilton, Director of the WWF International Arctic Programme. “The fact that a catastrophic spill might exceed the operating limits of existing oil spill response technologies is a strong argument for a moratorium until the response gap is filled.”

According to the report Oil Spill Response Challenges in Arctic Waters, arctic conditions can impact on both the probability that a spill will occur from oil and gas operations and the consequences of such a spill. The same conditions that contribute to oil spill risks (including lack of natural light, extreme cold, moving ice floes, high wind and low visibility) can also make spill response operations extremely difficult or totally ineffective.

“The Arctic offers the highest level of ecological sensitivity and the lowest level of capacity to clean up after an accident,” said James Leaton, Senior Policy Adviser, WWF-UK. “This combination makes it unacceptable to expose the Arctic to an unfettered scramble for oil.”

The report recognizes that significant efforts are ongoing to test and improve spill response technologies for use in arctic conditions. However, until such technologies are field-proven and market-ready, additional prevention and planning measures are required to eliminate oil spill risks during times when response operations are not feasible.

WWF has also called for an international mandatory instrument to regulate shipping in the Arctic, as shipping imposes great risks to the Arctic Environment. Routing, zero-discharge zones, areas to be avoided and obligations to keep a certain amount of “self-help” oil spill response equipment on board are among the needed measures.

The report can be downloaded at: http://assets.panda.org/downloads/nuka_oil_spill_response_report_final_jan_08.pdf

Adapted from materials provided by World Wildlife Fund.

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Nanotubes Help Advance Brain Tumor Research

Daily Science Journal (Jan. 30, 2008) — The potential of carbon nanotubes to diagnose and treat brain tumors is being explored through a partnership between NASA's Jet Propulsion Laboratory, Pasadena, Calif., and City of Hope, a leading cancer research and treatment center in Duarte, Calif.

Benham Badie, M.D., director of the Department of Neurosurgery and the Brain Tumor program at City of Hope, performs a minimally invasive procedure to surgically remove a pituitary tumor. Nanotube technology may help in the development of new treatments that would require only minimally invasive procedures no matter the location of the brain tumor. (Credit: City of Hope)

Nanotechnology may help revolutionize medicine in the future with its promise to play a role in selective cancer therapy. City of Hope researchers hope to boost the brain's own immune response against tumors by delivering cancer-fighting agents via nanotubes. A nanotube is about 50,000 times narrower than a human hair, but it length can extend up to several centimeters.

If nanotube technology can be effectively applied to brain tumors, it might also be used to treat stroke, trauma, neurodegenerative disorders and other disease processes in the brain, said Dr. Behnam Badie, City of Hope's director of neurosurgery and of its brain tumor program.

"I'm very optimistic of how this nanotechnology will work out," he said. "We are hoping to begin testing in humans in about five years, and we have ideas about where to go next."

The Nano and Micro Systems Group at JPL, which has been researching nanotubes since about 2000, creates these tiny, cylindrical multi-walled carbon tubes for City of Hope.

City of Hope researchers, who began their quest in 2006, found good results: The nanotubes, which they used on mice, were non-toxic in brain cells, did not change cell reproduction and were capable of carrying DNA and siRNA, two types of molecules that encode genetic information.

JPL's Nano and Micro Systems Group grows the nanotubes on silicon strips a few square millimeters in area. The growth process forms them into hollow tubes as if by rolling sheets of graphite-like carbon.

Carbon nanotubes are extremely strong, flexible, heat-resistant, and have very sharp tips. Consequently, JPL uses nanotubes as field-emission cathodes -- vehicles that help produce electrons -- for various space applications such as x-ray and mass spectroscopy instruments, vacuum microelectronics and high-frequency communications.

"Nanotubes are important for miniaturizing spectroscopic instruments for space applications, developing extreme environment electronics, as well as for remote sensing," said Harish Manohara, the technical group supervisor for JPL's Nano and Micro Systems Group.

Nanotubes are a fairly new innovation, so they are not yet routinely used in current NASA missions, he added. However, they may be used in gas-analysis or mineralogical instruments for future missions to Mars, Venus and the Jupiter system.

JPL's collaboration with City of Hope began last year, after Manohara, Badie and Dr. Babak Kateb, City of Hope's former director of research and development in the brain tumor program, discussed using nanostructures to better diagnose and treat brain cancer. Badie said his team's nanomedical research continues, and the next goal will be to functionalize and attach inhibitory RNA to the nanotubes and deliver it to specific areas of the brain.

The JPL and City of Hope teams published the results of the study earlier this year in the journal NeuroImage.

Badie says that JPL's contribution to City of Hope's nanomedicine research has been invaluable.

"The fact that we can get pristine and really clean nanotubes from Manohara's department is unique," he said. "The fact that we are both collaborating for biological purposes is also really unique."

The collaboration between JPL and City of Hope is conducted under NASA's Innovative Partnership Program, designed to bring benefits of the space program to the public.

Adapted from materials provided by NASA/Jet Propulsion Laboratory.

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